Holger Gerhardt (VIB/KU Leuven/Cancer Research UK/ MDC/BIH Berlin) has conducted a new study with Katie Bentley’s Lab (Cancer Research UK/BIDMC-Harvard Medical School) and are answering a common question asked in the field of developmental biology and tissue patterning, particularly in vascular biology, the question is: “What are the fundamental mechanisms controlling size and shape of tubular organ systems”. The most obvious and common way to enlarge a tube’s girth is to add more “bricks” or building blocks by proliferating the cells, although an alternative method of doing it has sprung up. Benedetta Ubezio, Raquel Blanco and other scientists who work as colleagues at Holger Gerhardt’s and Katie Bentley’s lab are now saying that rearranging the cells is a way that he blood vessels can switch from instead of just creating brand new branches of tube, to enlarging the circumference of the new branches as well.
WHAT EXPERTS HAVE TO SAY…
Holger Gerhardt: (VIB/KU Leuven/Cancer Research UK/ MDC/BIH Berlin): “This mechanism also drives vessel enlargement in disease models including a model for diabetic retinopathy and cancer. These insights might lead to new ways of looking at VEGF treatments for cancer.”
Katie Bentley (Cancer Research UK/BIDMC-Harvard Medical School): “This study emphasizes the need to search for mechanisms and tissue factors that alter the dynamics of core signaling pathways, and thus opens our eyes to new possible “temporal dynamic” modifiers in disease that can either explain pathology or open up new targets for unexpected treatments. ”
Holger Gerhardt (VIB/KU Leuven/Cancer Research UK/ MDC/BIH Berlin): “From a wider methodology perspective it is clear that this work would not have been possible without implementing predictive computational modeling to guide and refine the experimental approaches and analysis. The iteration between modeling and experimentation is what gave rise to the first synchronization hypothesis and ultimately allowed us to ask the right question and perform the key experiments. As such, it is another example of the power of collaborative interdisciplinary work that will increasingly become necessary to tackle the most challenging questions in science and society.”
Katie Bentley: “Untangling the complex dynamics of biological pathways in health or disease is almost impossible to do in ones’ head. Computer Simulations are an easy way to watch the process unfold in front of you to identify new lines of enquiry. It was electrifying to see those first unexpected synchronized fluctations and expanding vessels in our high VEGF simulations, and after the dedication of a team of biologists over many years, performing, sometimes gruelingly long experiments! We can see that putting model predictions to the test, a feat still rare even with growing computational studies, can truly lead biology in new directions.”
Holger Gerhardt (VIB/KU Leuven/Cancer Research UK/ MDC/BIH Berlin): “The ability to study fluctuations of gene expression live is fascinating, but requires complicated gene editing and transgenic approaches. Whilst this worked OK in the case of our embryonic stem cell derived cultures, the fact that dynamic signals don’t accumulate made it very hard to actually detect the low level signals in the tissue in vivo. We will need better, brighter reporters, whilst maintaining their ability to degrade rapidly, in order to watch this behavior unfold in real time in living organisms. This is one aspect we are working on now.”
Although Hospitals worldwide are looking at new angles for alternative treatments, one center stands out from the rest. Centro Hospitalario Internacional del Pacifico S.A. In Tijuana, always known CHIPSA, They’re really thinking outside the box, really striving towards the end of cancer and pushing away how things have “always been done,” instead they are bringing new innovative ideas and old therapies that have been long forgotten, they have saved many lives from cancer and will save many more…
If you or a loved one has recieved the horrifying diagnosis of cancer, any type of cancer, then you need CHIPSA. It’s that simple, there’s no better, safer or more effective way to fight it…
But Who The Heck Are They And What The Heck Do They Have?
CHIPSA Hospital is the most prestigious Gerson Therapy Center. They specialize in cancer and immunological treatments that have been proven to work but are next to impossible to get in the US.
What They Do…
Immunotherapy: CHIPSA practices “Holistic comprehensive immunotherapy” and is capable of reversing chronic degenerative diseases like: Lymphoma Melanoma, Multiple Myeloma, Hodgkin’s Disease, Atherosclerosis, Arthritis, Diabetes, Candida, Lupus, Asthma, ALS, Alzheimer’s, Multiple Sclerosis, Liver Disease, Kidney Disease, Paget’s Disease, Hepatitis, Allergies, Sjoegren’s Syn., Heart Disease, Crohn’s Disease, Grave’s Disease, Thyroid Disease, Hypertension, and other degenerative diseases
Coley’s Therapy: Invented in the late 19th century by a cancer surgeon by the name of William Coley, the fluid contains bacteria and toxins that actually infect the body and cause a fever, which then stimulates the immune system to fight malicious tumors. Along the principle of making the body a less comfortable enviroment for the cancer.
Gerson Therapy: The Gerson ‘cancer’ Therapy is a set of medical treatments which has cured innumerable cases of terminal cancer. When you get down to basics, it is a low-sodium organic diet that regenerates the body’s healing process by giving a helping-hand to the immune system and taking away any deficiencies in the body’s nutrients.
This is the future of fighting cancer, we must learn all we can and then make the best decision for us and our family. Chemotherapy is unreliable and many a time does more harm than good. CHIPSA is the answer.
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